Opioid and non-opioid analgesics

1. A synthetic analgesic agent which increases contractile activity of myometrium and relaxes the neck (cervix) of uterus was prescribed to a woman in labour. Indicate this agent.

A.* Promedolum (trimeperidine)

B. Omnoponum

C. Analginum (methamizole)

D. Morphine

E. Fentanylum

2. A patient has signs of acute poisoning by morphine: sharp miosis, loss of consciousness, decrease of the arterial blood pressure and Cheyne-Stokes respiration. Choose the proper antagonist to be given.

A.* Naloxonum

B. Camphor

C. Lobeline

D. Cytitonum

E. Cordiaminum (nikethamide)

3. A man of 26 years complaints of headache. Previously, the man suffered from peptic ulcer for the past 4 years. What drug is more preferable in this situation for the relief of his headache.

A.* Paracetamolum

B. Diclofenac-sodium

C. Acetylsalicylic acid

D. Ibuprofenum

E. Indomethacinum

4. A 30 years old man was admitted to a hospital due to fracture of the crus with dislocation and expressed pain syndrome. Promedolum (trimeperidine) was introduced to eliminate pain. Indicate the mechanism of action of this drug.

A.* Stimulation of the opioid receptors in the CNS.

B. Blockade of the opioid receptors in the CNS.

C. Stimulation of dopamine receptors in the CNS.

D. Blocade of GABA receptors in the CNS.

E. Blocade of dopamine receptors in the CNS.

5. Naloxone was introduced to a 25 years old woman because of intoxication by morphine. After injection the state of the woman became better. Indicate the mechanism of action of this drug.

A. *Blockade of the opioid receptors of the CNS.

B. Blockade of GABA receptors of the CNS.

C. Blockade of the serotonin receptors of the CNS.

D. Blockade of benzodiazepin receptors of the CNS

E. Stimulation of the opiod receptors of the CNS.

6. A drug addict was admitted to the emergency department in coma with signs of poisoning by opioid analgesics. What side effect of morphine contributed to the poisoning?

A. *Tolerance

В Euphoria

C. Obstipation

D. Inhibition of breathing

E. Reduction of diuresis

7. A 52-years-old patient who had been suffering from urolithiasis was delivered to the emergency department with renal colic. A doctor administered atropine together with opioid analgesic with spasmolytic activity to prevent development of the pain shock. Choose this drug.

A. *Promedolum (trimeperidine)

B. Tramadol

C. Ibuprofen

D. Ketorolac

E. Morphine

8. Nonopioid analgesic was administered to the patient with neuritis of nervus trigeminus. This drug has fast effect, short time of action, can cause allergic reaction of immidiate type. It may be indicated in tablets and solution for injections. Determine this drug.

A. *Analginum (metamizole)

B. Ibuprofen

C. Mefenamic acid

D. Piroxicam

E. Indomethacin

9. Pains in the small of the back developed after the lifting of gravity (heavy loads). Radiculitis was diagnosed. It is known from the anamnesis that the patient was suffering from ulcer of the duodenal bulb for a long period of time. Make the most rational choice of nonopioid analgesics :

A. *Meloxicam

B. Ortophenum (diclofenac sodium)

C. lndomethacin

D. Butadion

E. Ibuprofen

10. Gum bleeding arose in the patient after extraction of the tooth, rom anamnesis it was revealed that the patient suffered from rheumatic arthritis, and was treated with the anti-inflammatory agent acetyl-salicylic acid(aspirin). Indicate the reason of arisen bleeding.

A. *Suppression of synthesis of thromboxane

B. Promotion ol thrombolysis

C. Inhibition ot hemopoesis

D. Decreasing of blood coagulation

E. Suppression of synthesis of uric acid

11. A patient with respiratory disease with high temperature took the drug from the group of non-opioid analgesics. This drug exerts predominantly anti-inflammatory action which excels the salicilates and butadionum. It is highly absorbed in the intestine and acts long. The side effects appear often. Determine this drug.

A. *Indomethacin

B. Meloxicam

C. Ortophenum (diclofenac sodium)

D. Butadion

E. Ibuprofen

12. A patient with various complaints addressed to the doctor. After through clinical examination the following diagnosis was made: myositis, peptic ulcer of the stomach in remession, leukopenia. Determine the analgesic drug for the treatment of myositis to this patient.

A. *Paracetamol (acetaminophen)

B. Acetylsalicylic acid (aspirin)

C. Amitriptyline

D. Morphine

E. Butadionum (phenylbutazone)

13. Non-steroidal anti-inflammatory agents are used for the treatment of following pains, except:

A. * Fractures of bones

B. Headache

C. Arthritis

D. Neuritis

E. Toothache

14. Non-steroidal anti-inflammatory agent was administered to a patient with rheumatic polyarthritis. In several weeks weakness and indisposition were arisen. The clinical examination of the patient revealed necrotic quinsy and leucopenia. What drug could cause this complication?

A. * Analginum (Metamizole)

B. Paracetamolum

C. Nitrazepam

D. Omnopon

E. Morphine

15. Indicate the synthetic opioid analgasic which possesses analgesic activity 100-400 times more than morphine.

A.*Phentanyl

B. Promedolum (trimeperidine)

C. Pentazocin

D. Omnoponom

E. Codein

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