The agents influencing the blood system.

1. The patient was admitted to the traumatologic department due to fracture of chin bones, damages of soft tissues and massive bleeding. Examination revealed paleness of the skin, pain in palpation of area of trauma, swelling of the skin, bleeding on the whole surface of the wound. Specify a drug for local use to stop the bleeding.

A. * Thrombinum

B. Calcii chloridum

С. Vikasolum

D. Aminocapronic acid

E. Ambenum

2. Drugs delaying blood coagulation (anticoagulants) are used for prevention and treatment of thrombosis. Specify an anticoagulant which antagonist is protamine sulfate.

A. * Heparinum

B. Meodicoclmarin

C. Syncumarum

D. Phenilinum
E. Sodium hydrocitrate

3. A patient was delivered to a hospital with complaints of loss of appetite, decrease of body weight, fatigue, pain around the epigastric area. Examination of the blood revealed megaloblastic anemia. Specify the main agent for the treat­ment of this disease.

A. *Cyanocobalaminum

B. Ferri lastas

C. Folic acid

D. Fercovenum

E. Coamidum

4. Specify the antagonist of the anticoagulants with indirect action.

A. *Vikasolum

B. Fercovenum

С Pentoxylum

D. Protamini sulfas

E. Contrykalum

5. Specify the coagulant agent available for local use only (to stop bleedings from small blood vessels).

A. *Hemostatic sponge

B. Vikasolum

С Calcii chtoridum

D. Fibrinogen

E. Aminocapronic acid

6. Specify the thrombolytic agent which belongs to with direct action plasma proteins.

A. *Fibrinolysin

В. Streptokinase

C. Contrycalum

D. Urokinase

E. Streptodecase

7. Inhibition of leukopoiesis is observed in a 43 years old roentgenologist. The amount of leukocytes 3,5*10⁹/l. Specify the agent to be used for correction of leukopoiesis.

A. *Pentoxylum

B. Ferroplexum

С. Hemostimulinum

D. Cvanocobalaminum

E. Ascorbic acid

Vitamins

1. A 64 year old woman suffers from night blindness (hemeralopia). What vitamin drug should be recommended?

A. * Retinolum

B. Riboflavin

С. Tocopherolum

D. Pyridoxinum

E. Ascorbic acid

2. A 58 year old woman suffers from cerebral atherosclerosis. Complex of her pharmacotherapy includes drug of vitamin E & С. Which pharmacological effect of these drugs is the main for treatment of this disease?

A. * Inhibition of free-radical oxidation of lipids

B. Increase of gonadotropic hormones synthesis in the pituitary body

С. Decrease of glucocorticoids release by adrenals

D. Strengthening of the antitoxic function of the liver

E. Improvement of the coronary circulation

3. A patient who had been taking л vitamin drug for the prevention of cerebrovascular spastic reactions began to complain of unpleasnt feelings: hyperemia of the face and upper part of the body, vertigo, feeling of blood influx into the head. What drug may cause these side-effects

A. *Nicotinic acid

В. Tocopheroli acetas

C. Nicotinamidum

D. Thiamin/ bromidum

E. Calcii pangamas

4. A patient had been taking vitamin D for a long time for treatment of rickets. Soon the signs of vitamin D intoxication developed: loss of appetite, nausea, headache, fatigue, increase of body temperature, etc. What vitamin decreasing the toxic influence of vitamin D should be administered?

A *Vitamin A

B. Vitamin С

C. Vitamin В₁₂

D. Vitamin PP

E. Vitamin B₂

5. A 55 year old patient was admitted to the haemotological department with signs of acute anemia. After laboratory examination megaloblastic hyperchromic anemia was diagnosed, which drug must be administered to the patient first of all?

A. *Cyanocobalaminum

B. Hemostimulinum

C. Ferroplexum

D. Ferrum-Lek

E. Folic acid

6. A 55 year old patient suffering from hyperchromic anemia obtained long-term treatment with vitamin В₁₂ parenterally. Why the parenteral way of introduction of vitamin B₁₂ is prefered more than the peroral way?

A.*It isn't absorbed in the intestine in oral introduction due to deficit of gastromucoproiein

B. It is faster absored

С It is longer circulated in the blood

D. It is faster penetrated to the bone marrow

E. it isn't destroied in the liver

7. A patient has diarrhoea, dementia and dermatitis. What vitamin has to be included into the complex pharmacotherapy?

A. *Nicotinic acid

B. Thiaminum

C. Cyanocobalaminum

D. Panthotenic acid

E. Riboflavinum

8.There is an inhibited coagulation in the patient with bile ducts obstruction, bleeding due to the low level of absorbtion of a vitamin. What vitamin is in deficiency?

A. *Vitamin К

B. Vitamin D

С. Carotene

D. Vitamin A

E. Vitamin E.

9. A patient with diabetes mellitus is treated by injections of vitamin B1 to eliminate metabolic acidosis. Which biochemical mechanism of action of vitamin B1 ensures the positive effect?

A. * Activation of dehydrogenases of the Krebs cycle

B. Activation of adenylate cyclase

С. Blockade or phosphodiesterase

D. Acceleration of acetylcholine synthesis

E. Acceleration of adrenaline synthesis

10. Metabolic acidosis arose in a patient due to impairment of carbohy­drate metabolism and accumulation of ketoacids in the organism, indicate the vitamin drug which promotes its elimination due to decrease concentration of ketoacids.

A. *Thiamine

B. Pyridoxins

С. Folic acid

D. Riboflavine

E. Ascorbic acid

11.Apatient suffers from chronic alcoholism with the following symptoms: pain in arms and legs, impairment of skin sensitivity, muscle weakness, edemas and increased amount of pyruvate. Which vitamin drug should be prescribed to the patient?

A. * Thiamine

B. Ergocalciferol

C. Retinol

D. Rutin

E. Vikasoium (Menadione)

12. 55 years old patient was admitted to the hematological department with acute anemia: RBCs - 1,5 x 10¹²/litre; Hb - 80g%, colour index - 1,3. Hyperchromic anemia was diagnosed. Which drug should be administered for treatment of this disease?

A. *Cyanocobalamine

B. Ferroplexum

С. Hemostimuline

D. Ferrum-lek

E. Folic acid

13.Which of the acids below decreases permeability of connective tissue structures, possesses antioxidant activity due to ability to be transformed from the oxydized form into reduced and on the contrary?

A. * Ascorbic acid

B. Hydrochloric acid

C. Mefenamic acid

D. Aspirin (acetylsalicylic acid)

E. Aminocaproic acid

14. For synthesis of the basic substances of connective tissue (mucopolysaccharides and collagen) an essential agent is:

A. * Ascorbic acid

B. N icotinic acid

С. Folic acid

D. Salicylic acid

E. Acetylsalicylic acid

15. Radiation therapy is performed to the patient. What vitamin drug with antioxidant properties is necessary for administration to increase stability of tissues in this case?

A. * Ascorutinum

B. Vitamin B₆

С Thiamine chloride

D. Cyanocobaiamine

E. Folic acid

16. The woman of 25 years who anted to get thin was on a diet hich consisted of 2 cups of coffee ithout sugar, 3 crackers from white bread, 2 sausages or 2 eggs in a day within 1,5 months. The mass of a body has dropped on 5 kg, but there were developed strong headaches, often nasal bleedings, bleeding, sickness of gums, shaking of teeth, -.helling of sfcin and shedding of hair.What vitamin drug is expedient in this (ase?

A. *Ascorbic acid

B. Folic acid

C. Retinol acetate

D. Cyancobalamine

E. Vikasolum (Menadione)

17. The patient who was treated by a vitaminic drug for prophylaxis of vasospasms of the brain, has developed complaints of the unpleasant sensations related to taking of this medicine: reddening of the face and the upper half of a trunk, giddiness, sence of flush of blood to a head. For what drug the specified side-effects are characteristic?

A. *'Nicotinic acid

B. Nicotinamidum

C. Thiamine bromide

D. Tocoferol acetate

E. Calcium pangamate

18. Bioflavonoids (rutin, quercetin) possess all listed below pharmacodynamic effects, except for:

A. * Dilation of capillaries

B. Antioxidant activity

C. Inhibition of hyaluronidase activity

D. Decrease of permeability of capillary wall

E. Protections of ascorbic acid, assistance to its transport and accumulation

19. 64 years old woman suffers from hemeralopia (disturbance of vision in darkness). What vitaminic drug should be recommended her first of all?

A. *Retinoli acetate

B. Tocoferol acetate

C. Pyridoxin

D. Ascorbic acid

E. Riboflavin

20. What vitamin promotes growth and development of epithelial cells, including epidermal ones?

A. *Retinol

B. Ergocalciferol

C. Ascorbic acid

D. Nicotinic acid

E. Lipoic acid

21. 39 years old patient suffers from hyperkeratosis, disturbance of vision in darkness, frequent infectious diseases. What vitaminic drug should be administered for treatment .

A. *Retinol acetate

B. Pyridoxin

С. Riboflavin

D. Ergocalciferol

E. Tocoferol acetate

22. What vitamin is formed in skin under influence of ultraviolet radiation?

A. *Cholecalciferol

B. Ascorbinic acid

C. Retinole acetate

D. Calcium pantotenate

E. Riboflavin

23. To the child with signs of rachitis the pediatrist and the "dentist administered a liposoluble vitamin which influences an exchange of phosphorus and calcium in an organism, promotes sedimentation of calcium in bone tissue and dentins. Determine a drug.

A. *Ergocalciferol

B. Tocoferol acetate

С. Retinoli acetate

D. Vikasolum (Menadione)

E. Thyreoidinum

24. Parasthesia, xeroderma arid sticking out of fontanel are observsed at the 6 months child under the treatment by a vitaminic drug. Specify this drug.

A. *Ergocalciferol

B. Pyridoxine

С. Riboflavin

D. Retinoli acetate

E. Tocoferol acetate

25. The dentist administered to his patient liposoluble vitamin with antioxidant activity for treatment of parodontitis. Specify this vitaminic drug.

A. * Tocoferol acetate

B. Ascorbic acid

C. Rutin

D. Nicotinic acid

E. Ergocalciferol

26.A doctor administered tocoferol acetate to a patient with ischemic heart disease. What effect of a drug does the doctor expect?

A. *Antioxidant

B. Spasmolytic

С. Hypotensive

D. Increase of oxygen delivery to myocardium

E. Positive inotropic

27. What enzymatic drug is used with the purpose of dropping of density and rising of permeability of connective tissue structures?

A. *Lidase

B. Lipase

С. Cocarboxylase

D. Cholines terase

E. Amylase

Endocrine drug

1. After prolonged treatment of thyrotoxicosis with an antithyroid drug, suppressing synthesis of thyroid hormones in a thyroid gland, the patient complained of the dyspeptic disorders, appearance of a tumescence on the front surface of a neck. Analysis of the blood revealed leukopenia and agranulocytosis. With what antithyroid drug was the patient treated?

A. * Mercazolilum

B. Diiodotyrosine

С. Iodine

D. Radioactive iodine

E. Potassium perchlorate

2. The patient suffering from diabetes mellitus complained of flaccidity, apathy, difficulty of respiration. Investigation of the patient revealed: confused consciousness, paleness and dryness of the skin and mucous membranes, sunken eyes, sharp pointed features of the face. The blood pressure is 100/60 mmHg. Pulse is weak and frequent. Odour of acetone from the mouth. The diagnosis of hyperglycemic coma was given. Which drug should be introduced for the elimination of the given state?

A * Insulin

B. Glibutidum

С Bucarbanum

D. Protamine-zinc-insulin

E. Butamidum

3. Hypoglycemic state arose in the patient who had been suffering from diabetes mellitus and was treated with insulin's drug of prolonged action. Indicate the endocrine drug which should be introduce to eliminate this plate.

A. *Glucagonum

В Hydrocortisone

C. Triamcinolonum

D. Noradrenaline

E. Prednisotonum

4. Specify the hormonal agent which is used in diabetes insipidus.

A. *Adiurecrinum

B. Oxytocin

C. Insulin

D. L-thyroxin

E. Prednisolonum

5. Specify a synthetic analogue of glucocorticoid hormones.

A *Prednisolonum

В. Adrenaline

C. Pituitrinum

D. Cortisone

E. Testosterone

6. A patient, 42 years old, took glucocorticoids in relation with rheumatoid arthritis. In 3 weeks the signs of arthritis were almost eliminated and the patient stopped taking Им drugs. But a day after there was a relapse, and the new attack was significantly more severe than at the beginning of the disease. What's the reason of the developed complication?

A. *Decrease of release of glucocorticoids

B. Increase of methabolism of glucocorticoids

С. Slowing down of transport of glucocorticoids

D. Speeding-up of elimination of glucocorticoids

E. Increase of glucocorticoids' receptors adaptation

7. A woman, 28 years old, was admitted to a hospital in relation with danger of miscarriage. Earlier she had two cases of preliminary labor. Specify the drug of the hormone of corpus luteum that needs to be introduced in this case.

A. *Progesterone

B. Praegninum

С. Diazepam

D. Magnii sulfas

E. Tocopherol

8. In a woman during labor, weakness of labor activity is deter­mined. What hormone drug should be introduced for stimulation of myometrium contractions?

A. *Hormone of n. supraopticus of the hypothalamus (oxytocin)

В. Follicle stimulating hormone

С. Prolactin

D. Luteinizing hormone

E. Hormone of n. paraventricularis of the hypothalamus (vasopressin)

9. After removal of the thyroid in a patient the attacks of convulsions are observed. What drug needs to be administered?

A. *Parathyreoidin

B. Somatotropin

С. Insulin

D. Prednisolonum

E. L-thyroxin

10. A patient had been taking glucocorticoids for a long time. When the drug was withdrawn he developed the symptoms of disease aggravation, decreased blood pressure arid weakness. What is the reason of this condition?

A. *Appearance of adrenal insufficiency

B. Sensibilization

С. Habituation (tolerance)

D. Hyperproduction of ACTH

E. Cumulation

11. A patient with severe inflammatory disease had been treated by prednisolone during 10 months. Due to improvement of patients state the doctor has reduced a dose of prednisolone and added corticotropin. What purpose has he pursued, administering corticotropin?

A. *Stimulation of suprarenal glands activity

B. Potentiotion of drugs effects

C. Replacement of prednisolone

D. Decrease of side-effects of prednisolone

E. Prophylaxis of tolerance to prednisolone

12. A patient was treated for a long time by a glucocorticoid drug. After sharp stopping of taking a drug following complaints were arisen: undue fatigability, emotional lability, sleeplessness, headache, decrease of appetite, nausea. The syndrome was diagnosed. What drug should be administered for correction of this state?

A. *ACTH

B. Glucocorticoids

С. Adrenaline

D. Corticosteroids

E. Mineralocorticoids

13. Specify the drug of posterior pituitary hormone applied to stimulation of labor activity of uterus.

A. *Oxytocin

B. Dinoproston

С. Pachycarpin

D. Dinoprost

E. Salbutamol

14. A 25 years old woman was delivered to a maternity home for delivery. Due to uterine inertia a doctor administered her hormonsil agent. Indicate this drug.

A. *Oxytocin

B. Retabolilum

С. Progesterone

D. Gonadotropin chorionic

E. Testosterone

15. Specify the hormones entering into composition of pituitrin.

A. *Oxitocin and Vasopressin

B. Oxytocin and progesterone

C. Oxytocin and oestradiol

D. Vasopressin and oestradiol

E. Vasopressin and progesterone

16. To the patient after a subtotal resection of thyroid gland the drug of replaceable therapy is administered. Specify this agent.

A. * L thyroxine sodium

B. Potassium perchlorate

C. Mercazolilum

D. Rifathyreline

E. Potassium iodide

17. Impairment of enamel and dentine formation is diagnosed in a child owing to the under content of calcium ions in blood. What hormonal drug can be administered to correct this state?

A. *Calcitonin

B. Thyroxine

C. Somatotropinum

D. Prednisolone

E. Cortisone

18. Mercazolilum (methimazole) had been administered to the patient, suffering from thyrotoxicosis. What effect underlies antithyroid activity of a drug?

A. *Decrease of thyroid hormones production

B. Depression of production of thyrotropic hormone

С. Depression of uptake of iodine by thyroid gland

D. Destruction of cells of thyroid gland

E. Oppression of metabolism in thyroid gland

19. Convulsions were developed at the patient after thyreoidectomy. By usage of what drug is it possible to eliminate this state?

A. *Calcium chloride

B. Tubocurarine

С. Calcitrinum

D. Triiodothyronine

E. Ergocalciferol

20. At investigation of a sick woman hyperactivity of thyroid gland is revealed. What drug should be administered to her?

A. * Mercazolilum (methimazole)

B. L-thyroxine

С. Triiodothyronine

D. Lugol’s solution

E. Thyreoidinum

21. A drug of iodine is administer, to the patient, suffering from hyperthyroidism of an initial stage. What effect underlies antithyroid activity of this drug?

A. * Oppression of release by pituitary body of thyrotropic hormone

В. Oppression of activity of the enzymes participating in synthesis of iodine-containing hormones of thyroid gland

С. Activation of production by hypothalamus of thyroliberine

D. Inhibition of the process of iodation of hormones’ molecules

E. Destruction of tissue of thyroid glan

22. Radioiodine (J 131) is administered to a 65 years old patient suffering from Basedow’s disease, considering inefficiency of treatment by the basic drugs and impossibility of a surgical intervention. What is the mechanism of action of this agent?

A. * Causes destruction of follicles of thyroid gland

B. Inhibits functions of thyroid gland

С Oppresses synthesis of hormones of thyroid gland

D. Accelerates excretion of iodides from thyroid gland

E. Blocks entering of iodine in thyroid gland

23. Numbness of extremities and paresthesia were developed at the 52 years old patient soon after the operation of thyreoidectomy, hypocalcemia is laboratory diagnosed. What hormonal drug is necessary for administering?

A. * Parathyroidin

B. Thyreoidinum

С. Calcitrinum

D. Thyroxine

E. Triiodothyronine

24. The patient after removal of thyroid gland suffers from attacks of convulsions. What drug is necessary for administering in this case?

A. *Parathyroidin

B. Insulin

С. Prednisolone

D. Thyroxine

E. Somatotropin

25. Insulin was introduced to the patient, suffering from diabetes melliyus. What is the main mechanism of action of this agent?

A. * Activation of glucose transport from blood to tissues

B. Oppression of glycogenesis

C. Inhibition of transport of amino-acids

D. Activation of synthesis of triglycerides

E. Activation of glycogen synthesis

26. Hyperglycemic coma is developed at the patient, suffering from diabetes mellitus. What drug should be administered in this situation?

A. *Insulin of short action

B. Insulin of long duration of action

С. Drug from the group of biguanide derivatives

D. Insulin of intermediate duration of action

E. Drug from the group of sulfonylurea derivatives

27. Which agent from listed below should be introduced for treatment of hyperglycemic coma?

A. *Insulin

B. Metformin

С. Protamin-Zincum-insulin

D. Chlorpropamide

E Bytamidum (Carbutamide)

28. To the patient, suffering from diabetes mellitus the nurse has wrongly introduced almost double dose of insulin. In 2 hours sweating, tachycardia, convulsions and loss of consciousness has developed. Hypoglycemic coma is diagnosed. What drug should be introduced to the patient?

A. *Glucose

B. Insulin

С. Lydasum

D. Somatotropinum

E. Noradrenaline

29. A 60 years old patient has been suffering within 9 years from diabetes mellitus and is treated by insulin. 10 days ago his doctor has administered to him beta adrenoblocker propranolol (anaprilinum) due to arterial hypertension. In an hour after last introduction of propranolol hypoglyce­mic coma has developed. Indicate a reason of arising of hypoglycemia in this case?

A. * Oppression of glycogenolysis

B. Prolongation of action of insulin

C. Decrease of release of glucagon

D. Magnification of bioavailability of insulin

E. Diminution of absorption of glucose

30. A 60 years old patient has been suffering within 9 years from diabetes mellitus and is treated by insulin. 10 days ago his doctor has administered to him beta- adrenoblocker propranolol (anaprilinum) in connection with arterial hypertension. In an hour after last introduction of propranolol he has felt asthenia, darkening in eyes, arterial pressure was depressed and in some minutes the patient has lost consciousness. Indicate the condition which has developed at the patient.

A. * Hypoglycemic coma

B. Hyperglycemic coma

C. Cardiogenic shock

D. Sharp impairment of cerebral circulation

E. Allergic reaction

31. A 60 years old patient has been suffering within 9 years from diabetes mellitus and is treated by insulin. 10 days ago his doctor has administered to him hypotensive agent to treat arterial hypertension. In an hour after last introduction of this drug hypoglycemic coma has developed. Which of the numbered drugs could cause this complication?

A.* Propranolol (anaprilinum)

B. Prazozin

С. Verapamil

D. Captopril

E. Nifedipine

32. A 60 years old patient has been suffering within 9 years from diabetes mellitus and is treated by insulin. 10 days ago his doctor administered to him hypotensive agent to treat arterial hypertension. In an hour after last introduction of this drug hypoglycemic coma has developed. Which of the numbered drugs should be used for treatment of this state?

A. * Glucose

В. Insulin

C. Noradrenaline

D. Natrii hydrocarbonas

E. Bemegride

33. The state of the patient, suffering from diabetes mellitus was worsened after the injection of insulin with long action duration: general asthenia, cold sweat, tremor of extremities developed hypoglycemic coma was diagnosed. Intravenous injection of glucose solution didn’t cause improvement of the state. What drug should be used in this situation?

A. * Adrenaline

B. Insulin

C. Isadrinum (isoprenaline)

D Dobutamine

E. Dopamine

34. The 56-years patient complained of thirst and frequent emiction. After investigation in endocrinology the diagnosis of diabetes mellitus was established, and Butamidum (carbutamide) was administered to him. Determine the mechanism of action of this agent.

A. * Stimulates beta-cells of pancreatic islets of Langerhans

B. Promotes utilization of glucose by tissues of an organism

С. Facilitates glucose transport through cellular membranes

D. Oppresses beta-cells of pancreatic islets of Langerhans

E. Increases a level of glucose in a blood

35. What drug stimulating release of endogenic: insulin is a derivative of sulfonylurea with average action duration (8-24 hours)?

A. * Butamidum (carbutamide)

B. Buforminum

C. Metforminum

D. Gilipizid

E. Chlorpropamide

36. Specify a drug, which is suitable to be used in patients suffering from diabetes mellitus with lowered ability of pancreas to produce insulin

A. * Butamidum (carbutamide)

B. Insulin

С Adrenaline

D. Glucagon

E. Calcitrinum

37. The patient of advanced age addressed to the doctor with complaints of dryness in a mouth, polyuria, weight loss. At examination hyperglycemia and glycosuria are revealed. It is diagnosed: diabetes mellitus, II type (non insulin dependent), an intermediate degree of gravity. Which of the numbered drugs should be administered to the patient?

A. *Butamidum (carbufamide)

В. Insulin

С. Acarbose

D. Glucose

E. Adrenaline

38. At examination of 70 years old patient hyperglycemia is revealed. What drug is expedient for treatment of this state which is used oraly?

A. *Glibenclamide

B. Mercazolllum

C. Parathyroidin

D. Iinsulin

E. Cortisone

39. Indicate the synthetic antidiabetic drug from the group of biguanide derivatives.

A. *Metformin

B. Acarbose

С Butamidum (carbutamide)

D. Glibenclamide

E. Glipizid

40. The patient of 45 years complains of constant thirst and expressed polyuria. The level of glucose in blood plasma is normal, and in urine glucose misses. What drug should be chosen for his treatment?

A. *Adiurecrinum

B. Desoxycorticosterone

С Insulin

D. Hydrocortisone

E. Prednisolone

41.What drug oppresses absorption of glucose in small intestine?

A. * Acarbose

B. Insulin

С. Butamidum (carbutamide)

D. Metformin

E. Glucose

42. Acute bronchitis is arisen in a patient suffering from diabetes mellitus. What antimicrobial drug is undesirable for administering to this patient?

A. *Biseptol (co-trimoxazole -combined sulfonamide)

B Amptcillin (antibiotic)

С. Tetracycline (antibiotic)

D. Azithromycin (antibiotic)

E. Cefotaxim (antibiotic)

43. The patient's state requires introduction of glucocorticoids. How is t necessary to administer them taking into account physiological change of these hormones' content in a blood?

A.*2/3 of the dose in the morning, the rest in the afternoon

B. All dose in the evening

С. All dose in the morning

D. Evenly within day

E. 2/3 of the dose in the evening, the rest in the morning

44. Indicate the mechanism of antiinflammatory action of Prednisolone.

A. * Inhibition of phospholipase A2 activity

B. Inhibition of transcription

C. Inhibition of COX activity

D. Inhibition of translation

E. Stimulation of COX activity

45. A doctor had administered several drugs (anti-inflammatory, antibacterial and so on) to a patient who suffered from rheumatic carditis. After a while hyperglycemia has arisen at him. What group of drugs is (capable to cause such side-effect?

A. * Glucocorticoids

B. Nonsteroid anti-inflammatory drugs

С. Antibiotics of Penicillin group

D. Ascorbic acid

E. Sedatives

46. Specify synthetic analogue of glucocorticoid hormones.

A. *Prednisolone

В. Pituitrine

С Adrenaline

D. Cortisone

E. Testosterone

47. The patient suffering from severe form of diabetes mellitus is netted by insulin. Now his condition requires administering of antiinflammatory agent. Specify the drug which can demand correction of a dose of insulin?

A. * Prednisolone

В Diclofenac-sodium

C. Ibufrofen

D. Indomethacin

E. Butadionum (phenylbutazone)

48. The man of 50 years suffers from tuberculosis of the skin. Which of numbered drugs, used for treatment of dermal diseases, is contra-indicated to this patient?

A. * Prednisolone

B. Tetracycline

С. Sulfur ointment

D. Ergocalciferol

E. Retinol acetate

48. What drug cannot be used at infectious affections of skin?

A. * Prednisolone ointment

B. Gentamvcin ointment

С Tetracyclin ointment

D. Yellow mercury ointment

E. Brilliant green

50. The daily dose of what drug should be parted on unequal portions according to phases of a circadian rhythm?

A. *Dexamethasone

B. Indomethacin

С. Ibufrofen

D. Diclofenac-sodium

E. Butadionum (phenylbutazone)

51. Specify a drug from the group of glucocorticoids, which is poorly absorbed into the blood in application to the skin.

A. *Synaflanum (fluoclnolone)

B. Dexamethasone

C. Triamcinolone

D. Desoxycorticosterone

E. Prednisolone

52. The doctor has administered an ointment containing glucocorticoid to the patient suffering from allergic dermatitis. The advantage of this drug is - it is not absorbed into the blood from the skin. Specify this drug.

A. *Flumethasone

B. Dexamethasone

С. Becfomethasone

D. Hydrocortisone

E. Prednisolone

53. Glucocorticoid agent (Prednisolone) had been administered to the patient of 42 years who suffered from rheumatoid arthritis, in 3 weeks patient’s state had improved and he had discontinued taking of the drug. However in a day his condition was worsened. What was the reason of this complication?

A. * Production of glucocorticoids had dropped

B. Transport of glucocorticoids was inhibited

С. Elimination of glucocorticoids had been accelerated

D. Adaptation of receptors to glucocorticoids had strengthened

E. Metabolism of glucocorticoids had strengthened

54. After long-term treatment by glucocorticoid agent this drug was abolished, but patient’s state was worsened: exacerbation of the current disease, decrease of arterial pressure; asthenia had developed. Indicate a reason of the arisen condition.

A. * Insufficiency of suprarenal glands

B. Drug tolerance

С. Sensibilization

D. Hyperproduction of ACTH

E. Cumulative action

55. The patient of 60 years has tolerated mastectomy. After a course of radiation therapy the doctor has administered a synthetic drug of nonsteroid structure which eliminates stimulatory influence of oestrogens on tumoral growth. Specify this drug.

A. *Tamoxifen

B. Fosfestrol

C. Rubomvcin

D. Diethylstiibestrol

E. Cisplatin

56. The woman of 28 years was admitted to the department of pathology of pregnancy due to threat of abortion. In her anamnesis there are two events of premature birth. Specify a drug of the yellow body hormone which should be administered in this case.

A. * Progesterone

B. Praegninum

С. Diazepam

D. Magnesium sulfate

E. Vitamin E.

57. Cancer of mammary gland is diagnosed at the woman of 6 years. What hormonal drug should be administered?

A. *Testosterone

B. Synoestroium

C. Phenoboline

D. Progesterone

E. Insulin

58. Indicate the drug which stimulates synthesis of proteins, exerts positive influence on calcium and nitrogen exchange and also promotes increase of appetite and body weight.

A. * Retabolilum (nandrolone decanoate)

B. Prednisolone

C. Dexamethasone

D. Progesterone

E. Corticotropin

59. The doctor has administered Retabolilum (nandrolone decanoate) to a female patient after consolidation of fracture of a bone for acceleration of recovery, Indicate characteristic undesirable effect of this drug at women.

A. * Masculinization

B. Decrease of body weight

С. Catabolic effect

D. Feminization

E. Asthenia

60. A 19-year-old female suffers from tachycardia in resting condition, weight loss, excessive sweating, exophthalmos and irritability. What hormone would you expect to find elevated in her serum?

A. *Thyroxine

B. Cortisol

С. ACTH

D. Mineralocorticoids

E. Insulin

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