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Anti-inflammatory, antiallergic and other immunotropic agents.



1. A 40 year-old patient working as a driver suffers from chronic conjunctivitis of an allergic genesis. Which antihistamine drug' should be administered to a patient, taking into account his profession?

A. * Diazolinum

B. Dimedrolum

С. Diprazinum

D. Suprastinum

E. Ketotifenum

2. In a 55 years old patient or the 4,h day of treatment with indomethacinum gastric hemorrhage developed due to ulcering of gastric mucous membrane. By what is the ulcerogenic effect of the drug caused ?

A. *Decrease of synthesis of prostaglandin E1

B. Decrease of synthesis of prostaglandin E2

C. Decrease of synthesis of leucotriens

D. Decrease of synthesis of cyclic endoperoxydes

E. Decrease of synthesis of thromboxane

3. After prolonged taking of a drug in relation with acute respiratory disease a patient began to complain of headache, vertigo, noise in ears, nausea, epigastric pain. Specify the drug that might cause such clinical picture.

A *Acetylsalicylic acid

B. Vitamin С

C. Naphthyzinum

D. Bromhexinum

E. Midantanum

4. In a woman, 33 years old, after long-term pharmacotherapy of chronic polyarthritis arterial hypertension, redistribution of fatty tissue, menstrual disorders were observed. What drug did the patient take?

A. *Prednisolonum

B. Indomethacinum

C. Butadionum

D. Synaphlanum

E. Beclomethasonum

5. Specify the most typical side-effects of butadionum,

A. *Dispeptis disorders

B. Suppression of the CNS

C. Hypothermia

D. Arterial hypotension

E. Allergic reactions

6. Which drug is the most preferable to local treatment of allergic dermatitis?

A. *Hydrocortisone ointment

B. Hippophea oil

C. Furacilinum solution

D. Afethyisalicylate liniment
E. Ichthyolum ointment

7. The patient with systemic lupus erythematosus was treated for a long time by non-steroid anti-inflammatory agents. However, recently his condition has considerably worsened. Which drug is necessary to administer to the patient?

A. * Prednisolone

B. Analginum (Metamizole)

C. Dimedrolum (Diphenhydramine)

D. Thymalinum

E. Polyvitamins

8. The woman of 33 years on a phone of long-lasting medicamental therapy of chronic polyarthritis, began to mark herself increase of arterial pressure, change of allocation of fatty tissue (accumulation mainly in the area of the face and neck), disorder of menstrual cycle. What drug the patient took?

A. * Prednisolone

B. Indornethacin

C. Butadionum (Phenylbutazone)

D. Synaflanum (Fluoclnolone)

E. Beclomethasone

9. The 60 years old woman who had been suffered from arthritis of knee joint was treated for a long time by Dexamethasone. Indicate the mechanism of anti-inflammatory action of this drug?

A. *Blockade of phosphlipase A2

В Blockade of cyclooxygenase-1

С. Blockade of cyclooxygenase- 2

D. Blockade of folate synthase

E. Blockade of folate reductase

10. The patient suffering from arthritis has been treating for several months by glucocorticoid agent Dexamethasone. Recently he has begun to complain of nausea, frequent stomach aches. Clinical examination has revealed ulcer of the stomach. What is the mechanism of ulcerogenic action of glucocorticoids?

A Inhibition of protein synthesis due to activation of gluconeqgenesis

B. Blockade of prostaglandin synthase

C. *Impairment of microcirculation in gastric mucousa

D. Initiation of n. vagus

E. Blockade of gastrin synthesis

11. A patient suffers from systemic inflammatory affection of connective tissue. Indicate the drug inhibiting all phases of inflammation which should be administered to the patient?

A. *Dexamethasone

В. Butadionum (Phenylbutazone)

С. Contrycal (Aprothtin)

D. Indomethacine

E. Diclofenac-sodium

12. Nonsteroid anti-inflammatory agents are effective at treatment of rheumatic disease owing to ability to oppress:

A. *Cyclooxygenase-2

B. Phospholipase-A2

C. Cyclooxygenase-1

D. Adenylatcyclase

E. Peroxidase

13. It is known, that nonsteroid anti-inflammatory drugs are widely used for treatment of rheumatic disease. They influence what of inflammatory process?

A. *Exudative

B. Phase of alteration

C. Phase of a proliferation

D. All phases of an inflammation

E. Autoimmune

14. The patient was treated by nonopioid analgesic due to backache. In several days he started to complain of dyspeptic disorders and stomachache (in anamnesis the patient had hyperacidic gastritis). Indicate the reason of the arisen complication.

A. * Inhibition of synthesis of prostaglandins in gastric mucosa

B. Stimulation of parasympathetic innervation by the stomach

C. Inhibiton of mucous production by the gastric mucosa

D. Inhibition of regeneratory activity of the gastric mucosa

E. Inhibition of organotrophic sympathetic influences upon the stomach

15. Following signs have developed at the patient after several days of treatment by the drug with analgesic, antipyretic and anti-inflammatory activity: headache, giddiness, sonitus, nausea, pain in epigastric area. Specify the drug which could produce similar clinical pattern.

A. * Aspirin

B. Naphthyzinum (naphazoline)

C. Bromhexinum

D. Midantanum (amantadine)

E. Vitamin С

16. The doctor has administered an ointment containing anti-infiammatory agent from the group of pyrazolone derivatives to the patient with arthritis of maxillofacial joint. What agent is contained in the ointment?

A. * Butadionum (phenylbutazone)

B. Mefetmmic acid

С. Ibufrofenum

D. Indomethacinum

E. Diclofenac-sodium

17. Indicate the drug from the group of nonsteroid anti-inflammatory agents which exerts the most prominent anti-inflammatory action in collagenoses?

A. *Iindomethacinum

B. Aspirin (acetylsalicylic acid)

С. Ibuprofenum

D. Butadionum (phenylbutazone)

E. Ortophenum (diclofenac-sodium)

18. The 55 years old patient, developed gastric hemorrhage on the 7-th day of treatment with Indomethacinum. Indicate the pharmacological effect of the drug which explains this complication.

A. * Diminution of formation of Prostaglandin El

B. Diminution of formation of letuotrien

С Diminution of formation of Prostaglandin E2

D. Diminution of formation of cyclic endoperoxides

E. Diminution of formation of thromboxane

19. Reduce of influence on which molecular substrate leads to decrease of ulcerogenic action of nonsteroid anti-inflammatory agents?

A. *Cyclooxvgenase-1

B. Kallikrein

C. Lysosomal enzymes

D. Cyclooxvgenase-2

E. Adenylate cyclase

20. The 63 years old patient with arthritis on a background of treatment by aspirin (acetyisalicylic acid) has complained of nausea, gravity in epigastrium. The doctor has abolished aspirin and has administered the antiinflammatory agent from the group of selective COX-2 inhibitors. Indicate this drug.

A. *Meloxicam'

B. Voltarenum (diclofenac-sodium)

С. Indomethacinum

D. Naproxenum

E. Butadionum (phenylbutazone)

21. Dimedrolum (diphenhydramine) is administered to a patient with urticaria to reduce itching rashes on the skin. What mechanism provides its efficiency in this case?

A. * Competitive blockade of HI-histamine receptors

B. Inhibition of synthesis of histamine

С. Suppression of release of histamine

D. Acceleration of histamine destruction

E. Blockade of H2-his famine receptors

22. What drug should be administered to the patient who suffers from rashes due to allergic reaction accompanied by reddening, edema, and strong itch of skin which causes sleeplessness?

A. *Dimedrolum (diphenhydramine)

B. Nitrazepamum

C. Chlorall hydrate

D. Natrii oxybutyrate (oxybate sodium)

E. Phenobarbitalum

23. The patient with allergic rhinitis s taken antihistamine drug PO. In an hour the patient felt dryness in mouth, retardation and sleepiness. Indicate this drug.

A. *Dimedrolum (Diphenhydramine)

B. Diazolinum (Mebhydrolin)

C. Phenobarbitalum

D. Diazepamum

E. Paracetamolum

24. Indicate "day time" antihistamine agent (with the least expressed sedative and hypnotic activity).

A. *Diazofinum (Mebhydroline)

B. Dirnedrplum diphenhydramine)

C. Diprazinum (Promethazine) 1

D. Tavegilum (Clemastine}

E. Suprastinum (Chloropyramine)

25.A 40 years old outpatient (driver) suffers from chronic conjunctivae, of allergic genesis. What antihistamine drug is necessary to administer taking into account his occupation?

A. *Diazolinum (Mebhydroline)

B. Diprazinum (Promethazine)

C. Suprastinum (Chloropyramine)

D Dimedrolum (Diphenhydramine)

E. Ketotifenum

26. It is necessary to administer antihistaminic agent to a patient work requires mental concentration. Indicate this drug.

A. * Diazolinum (Mebhydroline)

B. Dimedrolum (Diphenhydramine)

C. Diprazinum (Promethazine)

D. Suprastinum (Chloropyramine)

E. Phencarolum (Ouifenadine)

27 It is necessary to administer antihistaminic agent to a woman suffering from seasonal vasomotor rhinitis, who works as a dispatcher on the railway. Indicate the drug from this group which doesn’t possess sedative and hypnotic properties.

A. * Diazolinum (Mebhydroline

B. Dimedrolum (Diphenhydramine)

C. Diprazinum (Promethazine)

D. Suprastinum (Chtoropyraine)

E. Tavegilum (Clemastine)

28. A girl was treated with antibi­otic from the group of semisynthetic Penicillins due to acute bronchitis. On the 3rd day of treatment allergic dermatosis has developed. Indicate an antiallergic drug which should be administered to the patient.

A. * Suprastinum (Chloropyramine)

B. Levamisole

С. Aspirin (Acetylsalicylic acid)

D. Biseptol (Co-trimoxazole)

E. Mefenamic acid

29. Allergic dermatitis has been diagnosed at the patient of 43. The doctor has administered to him complex therapy including the blocker of HI-histamine receptors. Indicate this drug.

A. *Diprazinum (promethazine)

B. Cromolin sodium (cromoglicic acid)

C. Prednisolone

D. Adrenaline

E. Hydrocortisone

30. Indicate the group of antiallergic agents which loratadine belongs to.

A. * Blockers of histamine receptors

B. Membrane stabilizers

C. Antagonists of leucotriene receptors

D. Glucocorticoids

E. Blockers of serotonine receptors

31. Treatment by anti-inflammatory drugs was administered to the patient with rheumatic endocarditis. After a while hyperglycemia was him. What group of drugs is capable to provoke such side-effect?

A. * Glucocorticoids

B. Antibiotics of the group of Penicillins

C. Ascorbic acid

D. Sedatives

E. Nonsteroid anti-inflammatory agents

32. The patient of 35 years, suffer­ing from bronchial asthma, is hospital­ized in a state of anaphylactic shock. What of the numbered drugs is neces­sary to introduce first of all as first aid?

A. *Adrenaline

B. Dimedrolum (diphenhydramine)

С. Chromoglicic acid

D. Salbutamol

E. Ephedrine

33. The patient of 35 years, suffering from bronchial asthma, is hospitalized in a state of anaphylactic shock. What of the numbered drugs is necessary to introduce first of all as first aid?

A. *Adrenaline

B. Dimedrolum (diphenhydramine)

С. Chromoglicic acid

D. Salbutamol

E. Ephedrine

34. Anaphylactic shock was developed at the patient after intracutaneous test on sensitivity to Penicillin. The doctor had administered a drug which eliminated bronchospasm and arterial hypotension, indicate this drug.

A. * Adrenaline

B. Noradrenaline

С. Mesatonum (Phenylephine)

D. Atropine

E. Salbutamol

35. Many kinds of pathological states (inflammation, pulmonary edema, shock of different origin) are accompanied by violation of permeability of vessels. Which of the listed below drugs can be used for elimination of this reaction at any of the termed states?

A. * Prednisolone

B. Indomethacinum

C. Dimedrolum (diphenhydramine)

D. Aspirin (acetylsalicylic acid)

E. Beclomethasone

36. Indicate the drug which is the most expedient for using for topical treatment of allergic dermatitises?

A. *Hydrocortisone ointment

B. Solution of furacilinum (nitcofural)

C. Liniment of n>ethylsalicylate

D. Ointment of ichthyolum (ichthammot)

E. Sea buckthorn oil (Oleum Hippophae)

37. The patient with chronic relapsing dermatitis of allergic genesis requires treatment by a glucocorticoid agent. Indicate the drug from this group which exerts only local action on skin and does not cause systemic side-effects.

A. * Synaflanum (fluocinolone)

B. Prednisolone

C. Hydrocortisone

D. Dexamethasone

E. Triamcinolone

38. A doctor administered chromoglicic acid to the patient suffering from bronchial asthma to prevent attacks. Indicate the principle of action of this drug.

A. *Stabilization of membranes of mast cells

B. Binding of free histamine

C. Decrease of concentrations of immunoglobulins

D. Inactivation of histamine

E. Blockade of histamine receptors

39. A 45 years old patient suffers horn seasonal allergic rhinitis related lo blooming of ragweed. What agent should be used for prevention of this disease?

A. *Ketotifenum

В. Phencarolum (quifenadine)

С. Diazolinum (mebhydroline)

D. Tavegilum (clemastine)

E. Dimedrolum (diphenhydramine)

40. The patient took Levomycetinuin (chloramphenicole) for a long time without doctor’s permission. Now the patient’s examination revealed leucopnia. What drug should be administered for stimulation of leucopoiesis.

A.* Pentoxytum

В. Methotrexate

C. Mercaptopurine

D. Cyancobalamine

E. Prednisolone

41. The patient with chronic infection disease requires treatment with specific immunostimulant agent. Indicate this drug.

A. *Pentoxylum

B. Methotrexate

C. Mercaptopurine

D. Actinomycin

E. Cyclophosphanum

42. 48 years old woman who is from exacerbation of chronic pneumonia requires treatment with stimulant agent. Indicate this drug.

A. *Thymalinum

B. Sulfocamphocainum

C. Biseptol (co-trimoxazole)

D. Dimedrolum (diphenhydramine)

E. Levamisole

43. Indexes of immune response are worsened in a patient during chemotherapy of malignant tumour. What drug should be administered in this state?

A. * Thymalinum

B. Cyancobalamine

C. Iron preparations

D. Prednisolone

E. Acetylsalicylic acid

44. A drug from the group of immunostimulant which is an analogue of natural biogenic substrate and almost doesn’t exert side effects is administered to a 4 years old child. Indicate this drug.

A. * Interferon

B. Prodigiosanuin

С. Thymalinum

D. Pyrogenatum

E. Levamisole

45. Indicate the immunostimulant drug which is also well known as anthelmintic agent.

A. * Levamisole

B. Interferon

С. Methyluracil

D. Pyrantelum

E. Natrium nucleinate

46. A patient suffering from chronic generalized parodontics requires the treatment with immunostimulant agent which possess anthelmintic activity. Indicate this drug.

A. *Levamisole

B. Seeds of pumpkin

С. Pyrantelum

D. Chloxile

E. Piperazine adipate

47. Indicate the drug which significantly increases body temperature.

A. *Pyrogenatum

B. Acetylsalicylic acid

C. Methyluracil

D. Aminazine (Chlorpromiazine)

E. Molgramostim

48. A 45-year-old woman suffers from allergic seasonal coryza caused by Ambrosia blossoming. What drug from the group of stabilizers of mast cells can be used for prevention of the disease?

A. *Ketotifen

В. Phencaroi

C. Tavegil

D. Dimedrol

E. Diazoline

 




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